MICROBIAL MOLECULAR GENETICS

About this Course

  • 64 students enrolled
  • 1 instructors

Course Description

This course introduces students to the basic molecular features in a prokaryotic system. It illustrates how these molecular features underlie DNA replication, transcription, gene recombination and translation of proteins. How genes are being expressed and manipulated will also be discussed. After this course you will gain a better understanding on the fascinating world of microbial genetics. With this course, you will build a strong foundation upon which the rest of your study and future career will be well supported. Your success will be supported by the UFuture-MOOC's online platform. You will be provided with additional questions and material for download. Come and join us to learn whenever and wherever you are via online platform.

Course Learning Outcomes

1 ) Explain the structure and organization of nucleic acids, as well as the processes of DNA replication, protein synthesis and gene transfer in microorganism. ( C2 )
2 ) Elucidate the mechanisms for regulation of gene expression in a prokaryotic system. (C4)
3 ) Discuss the current trend and application of microbial molecular genetics (C2)

Course Details

STATUS : Open
DURATION : FLEXIBLE
EFFORT : 3 hours per week
MODE : 100% Online
COURSE LEVEL : Beginner
LANGUAGE : English
CLUSTER : Science & Technology ( ST )

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 Syllabus

1.1 Evidence of DNA as the genetic material
1.2 The composition and structure of DNA and RNA
1.3 The organization of DNA in chromosomes
1.4 Extrachromosomal genetic elements e.g. plasmid, transposon

2.1 Principles of DNA replication (Models of DNA Replication)
2.2 Meselson & Stahl Experiment
2.3 Molecular model of DNA replication
2.4 DNA Polymerases: structure and function

3.1 Transfer of genetic information: the central dogma
3.2 Structure and function of mRNA
3.3 Transcription in prokaryotes
3.4 Transcription and RNA processing in eukaryotes

4.1 Chemical and molecular structure of proteins
4.2 The nature of genetic codes
4.3 Ribosome structure and functions
4.4 Stages of translation

5.1 Horizontal Gene Transfer (HGT)
5.2 Transformation
5.3 Generalised and specialised transduction
5.4 Conjugation
5.5 Significance of gene transfer

6.1 Overview of the regulation of gene expression in bacteria
6.2 Constitutive, inducible and repressible gene expression
6.3 Positive and negative control of gene expression
6.4 The Lactose operon in E. coli
6.5 The Tryptophan operon in E. coli

7.1 Genome editing using CRISPR-Cas9 System
7.2 Antimicrobial Resistance

Our Instructor

DR. NORASHIRENE BINTI MOHAMAD JAMIL

 Course Instructor
UiTM Shah Alam

 Frequently Asked Questions

A1 : Virtual simulation for special topic

A2 : How to compare and contrast the mechanisms of DNA replication in prokaryotes and eukaryotes
How to compare and contrast the mechanisms of gene expression in prokaryotes and eukaryotes
How to describe gene expression and regulation in prokaryotes
How to describe several mechanisms of Horizontal Gene Transfer (HGT)
How to discuss the current trend and application of microbial molecular genetics

A3 : Dr Norashirene Mohamad Jamil (Ph.D)
Senior Lecturer
School of Biology,
Faculty of Applied Sciences
Universiti Teknologi MARA
40450, Shah Alam, Selangor.

Alternative Email: [email protected]
Mobile Contact: +6012-3043227

Expertise and interest - Molecular Biology, Microbiology, Microbial Genetics, Antibiotic Resistance, Transfer of Mobile Genetic Elements.

A4 : Estimated 8 weeks
3 hours per week

A5 : No, there is no requisite for this course

A6 : An individual's ability to assess, acquire and communicate information in a fully digital environment is expected.
Digital literacy which can be defined as digital tool knowledge combined with critical thinking and social engagement skills are needed.

A7 : Students are expected to be an independent active learner assisted with various study materials supported by the instructor. Students are encouraged to actively participate in group discussions and activities.