BASIC PRINCIPLES OF MEDICINAL CHEMISTRY

About this Course

  • 60 students enrolled
  • 3 instructors

Course Description

Modern pharmacy practice involves the dispensing of drugs and advice concerning their use. As experts in the therapeutic use of medications and pharmaceutical care, pharmacists routinely provide therapeutic evaluations, recommendations, and patient counseling on the safe, appropriate, and cost-effective use of medications. Thus, a comprehensive understanding of the chemical basis of drug action is required to arm pharmacy students with the necessary knowledge and position them as chemical experts at the interface with biology and medicine in a health care team. This course provides students with knowledge of chemistry that are relevant to the study of pharmaceutical drugs e.g. stereochemistry, physicochemical properties, drug-target interaction. Additionally, processes of drug discovery and rational drug design will be covered.

Course Learning Outcomes

1 ) Demonstrate ability to solve drug therapy related problems by analysing functional groups present on drug molecules
2 ) Describe the relationship between chemical structure and physicochemical properties of drugs, and their biological activity and efficacy

Course Details

STATUS : Open
DURATION : FLEXIBLE
EFFORT : 1-2 hours per week
MODE : 100% Online
COURSE LEVEL : Beginner
LANGUAGE : English
CLUSTER : Science & Technology ( ST )

Join this course

 Syllabus

Definition of medicinal chemistry
General concepts in medicinal chemistry
Fields that interface with medicinal chemistry
What are drugs and why do we need new ones?

Natural Products in Drug Discovery and Development
Secondary Metabolites
Synthetic Chemistry
In silico drug discovery

Introduction to the drug action
Pharmacokinetic phase (ADME)
Pharmacodynamic phase

Introduction
Physical Properties
Features Governing Drug Action in Active Site
Structurally Specific Drugs
Structurally Non-Specific Drugs
Factors Governing Ability of Drugs to Reach Active Site
Absorption, Distribution, Metabolism, Excretion

Stereochemistry and Drug Action
Stereochemistry and Biological Activity
Isosterism and Bio-Isosterism

General pathways of drug metabolism and sites of drug biotransformation
Role of Cytochrome P-450 Monooxygenases in oxidative biotransformation
Phase I Metabolism
Phase II Metabolism
Factors Affecting Drug Metabolism
Pharmacokinetics of metabolites
Drug metabolism and drug design

Proteins, Enzymes, and Nucleic Acids as Drug Targets
Receptors: Structure, Function and Signal Transduction Role of the receptor

Our Instructor

PROFESOR MADYA DR FAZLIN BTE MOHD FAUZI

 Course Instructor
UiTM Kampus Puncak Alam

PROFESOR DR AHMED MAHMOUD AHMED ALAFIFY

 Course Instructor
UiTM Kampus Puncak Alam

PROFESOR MADYA DR SYED ADNAN ALI SHAH

 Course Instructor
UiTM Kampus Puncak Alam

 Frequently Asked Questions

A1 : An understanding of basic organic chemistry is needed, as well as an enthusiasm to learn!

A2 : The course will be taught fully in English.