Course Syllabus
Introduction to general principle of toxicology
1.1 Overview of toxicology history.
1.2 Definition of common toxicology terms and classification of toxic agents.
1.3 Overview of toxicity spectrum and evaluation.
1.4 Overview of risk assessment.
Hepatotoxicity
2.1 Overview of liver physiology and its role in detoxication
2.2 Mechanisms and types of DILI
2.3 Reasons for the susceptibility of the liver to toxicity
2.4 Introduction to common and emerging hepatotoxicants
2.5 Signs and symptoms of DILI
2.6 Assessment of liver function
Nephrotoxicity
3.1 Overview of kidney physiology
3.2 Biochemical mechanisms/mediators of renal cell injury
3.3 Reasons for the susceptibility of the kidney to toxicity
3.4 Therapeutic agents causing kidney toxicity: acetaminophen, NSAIDs, aminoglycosides, amphotericin B, cyclosporine, cisplatin and radiocontrast agents.
3.5 Common signs and symptoms of toxicity
3.6 Assessment of renal function
Respiratory toxicity
4.1 Overview of the respiratory tract structure and function
4.2 General principles in the pathogenesis of chemical-induced lung damage
4.3 Lung’s acute and chronic responses to injury
4.4 Agents causing lung toxicity
4.5 Evaluation of toxic lung damage
Metal toxicity
5.1 Introduction to metal toxicity and its mechanism of action
5.2 Discuss metals antagonism
Pesticide toxicity
6.1 Introduction to types of pesticides
6.2 Mechanisms involved in pesticides toxicity
Reproductive toxicity
7.1 The mechanisms of teratogenicity
7.2 Examples of teratogents
7.3 The mechanisms involved in endocrine toxicity
7.4 Agents causing endocrine toxicity
7.5 Signs and symptoms of toxicity
Poisoning and clinical management
8.1 To focus on clinical management of poisoning by:
8.1.1 Non-opioid analgesics, anti-pyretics and anti-rheumatics
8.1.2 Diuretics, mineralocorticoids and its inhibitors, and drugs used to regulate uric acid metabolism
8.1.3 Pesticides and organic solvents
8.1.4 Topical agents used to treat diseases of the skin and ENT.
1.1 Overview of toxicology history.
1.2 Definition of common toxicology terms and classification of toxic agents.
1.3 Overview of toxicity spectrum and evaluation.
1.4 Overview of risk assessment.
Hepatotoxicity
2.1 Overview of liver physiology and its role in detoxication
2.2 Mechanisms and types of DILI
2.3 Reasons for the susceptibility of the liver to toxicity
2.4 Introduction to common and emerging hepatotoxicants
2.5 Signs and symptoms of DILI
2.6 Assessment of liver function
Nephrotoxicity
3.1 Overview of kidney physiology
3.2 Biochemical mechanisms/mediators of renal cell injury
3.3 Reasons for the susceptibility of the kidney to toxicity
3.4 Therapeutic agents causing kidney toxicity: acetaminophen, NSAIDs, aminoglycosides, amphotericin B, cyclosporine, cisplatin and radiocontrast agents.
3.5 Common signs and symptoms of toxicity
3.6 Assessment of renal function
Respiratory toxicity
4.1 Overview of the respiratory tract structure and function
4.2 General principles in the pathogenesis of chemical-induced lung damage
4.3 Lung’s acute and chronic responses to injury
4.4 Agents causing lung toxicity
4.5 Evaluation of toxic lung damage
Metal toxicity
5.1 Introduction to metal toxicity and its mechanism of action
5.2 Discuss metals antagonism
Pesticide toxicity
6.1 Introduction to types of pesticides
6.2 Mechanisms involved in pesticides toxicity
Reproductive toxicity
7.1 The mechanisms of teratogenicity
7.2 Examples of teratogents
7.3 The mechanisms involved in endocrine toxicity
7.4 Agents causing endocrine toxicity
7.5 Signs and symptoms of toxicity
Poisoning and clinical management
8.1 To focus on clinical management of poisoning by:
8.1.1 Non-opioid analgesics, anti-pyretics and anti-rheumatics
8.1.2 Diuretics, mineralocorticoids and its inhibitors, and drugs used to regulate uric acid metabolism
8.1.3 Pesticides and organic solvents
8.1.4 Topical agents used to treat diseases of the skin and ENT.
Frequently Asked Questions
Q1 : Who should I contact for more information on the course?
A1 : Please contact the resource person, Dr Nur Syamimi Ariffin, by email at [email protected]
Q2 : Are all topics in the syllabus will be covered in this MOOC?
A2 : Most of the topics in the syllabus are covered in this MOOC and a few topics are reserved for Micro-credential in the future.
Q3 : Do I need to pay for this course?
A3 : This course is currently open for anyone interested.
Q4 : Do I have to be a pharmacist to join this course?
A4 : Anyone with the background of science and biology can join the course.
A1 : Please contact the resource person, Dr Nur Syamimi Ariffin, by email at [email protected]
Q2 : Are all topics in the syllabus will be covered in this MOOC?
A2 : Most of the topics in the syllabus are covered in this MOOC and a few topics are reserved for Micro-credential in the future.
Q3 : Do I need to pay for this course?
A3 : This course is currently open for anyone interested.
Q4 : Do I have to be a pharmacist to join this course?
A4 : Anyone with the background of science and biology can join the course.