TOXICOLOGY

About this Course

  • 95 students enrolled
  • 4 instructors

Course Description

This course introduces students to a general concept and principle of toxicology and its context in human health problems. Also, students will be introduced to the concept of risk assessment and toxicity evaluation. They will be informed about various toxic agents including drugs, their effects on target organs, and their mechanisms of toxicity. Students will also be introduced to clinical management of poisoning by top five substances that lead to hospitalization and death in Malaysia.

Course Learning Outcomes

1 ) Demonstrate problem solving skills in treating and managing poisoning.
2 ) Explain the mechanisms through which the vital organs respond to toxic agents and symptoms/signs of toxicity.
3 ) Illustrate general concepts and principles of toxicology and its relevance in human health problems.

Course Details

STATUS : Open
DURATION : FLEXIBLE
EFFORT : 2 hours per week
MODE : 100% Online
COURSE LEVEL : Beginner
LANGUAGE : English
CLUSTER : Science & Technology ( ST )

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 Syllabus

1.1 Overview of toxicology history.
1.2 Definition of common toxicology terms and classification of toxic agents.
1.3 Overview of toxicity spectrum and evaluation.
1.4 Overview of risk assessment.

2.1 Overview of liver physiology and its role in detoxication
2.2 Mechanisms and types of DILI
2.3 Reasons for the susceptibility of the liver to toxicity
2.4 Introduction to common and emerging hepatotoxicants
2.5 Signs and symptoms of DILI
2.6 Assessment of liver function

3.1 Overview of kidney physiology
3.2 Biochemical mechanisms/mediators of renal cell injury
3.3 Reasons for the susceptibility of the kidney to toxicity
3.4 Therapeutic agents causing kidney toxicity: acetaminophen, NSAIDs, aminoglycosides, amphotericin B, cyclosporine, cisplatin and radiocontrast agents.
3.5 Common signs and symptoms of toxicity
3.6 Assessment of renal function

4.1 Overview of the respiratory tract structure and function
4.2 General principles in the pathogenesis of chemical-induced lung damage
4.3 Lung’s acute and chronic responses to injury
4.4 Agents causing lung toxicity
4.5 Evaluation of toxic lung damage

5.1 Introduction to metal toxicity and its mechanism of action
5.2 Discuss metals antagonism

6.1 Introduction to types of pesticides
6.2 Mechanisms involved in pesticides toxicity

7.1 The mechanisms of teratogenicity
7.2 Examples of teratogents
7.3 The mechanisms involved in endocrine toxicity
7.4 Agents causing endocrine toxicity
7.5 Signs and symptoms of toxicity

8.1 To focus on clinical management of poisoning by:
8.1.1 Non-opioid analgesics, anti-pyretics and anti-rheumatics
8.1.2 Diuretics, mineralocorticoids and its inhibitors, and drugs used to regulate uric acid metabolism
8.1.3 Pesticides and organic solvents
8.1.4 Topical agents used to treat diseases of the skin and ENT.

Our Instructor

DR. NUR SYAMIMI BINTI ARIFFIN

 Course Instructor
UiTM Kampus Puncak Alam

PROFESOR DR MIZATON BINTI HAZIZUL HASAN

 Course Instructor
UiTM Kampus Puncak Alam

PROFESOR MADYA DR LIM SIONG MENG

 Course Instructor
UiTM Kampus Puncak Alam

PROFESOR MADYA DR FAZLIN BTE MOHD FAUZI

 Course Instructor
UiTM Kampus Puncak Alam

 Frequently Asked Questions

A1 : Please contact the resource person, Dr Nur Syamimi Ariffin, by email at [email protected]

A2 : Most of the topics in the syllabus are covered in this MOOC and a few topics are reserved for Micro-credential in the future.

A3 : This course is currently open for anyone interested.

A4 : Anyone with the background of science and biology can join the course.